Joint Ventures

Chicago Labs  is a joint venture established in November 2002 to acquire four patents from the University of Illinois, USA, on an exclusive worldwide basis.

Chicago Labs is a Chicago-based specialty pharmaceutical company conducting research in four areas including pain, cancer, alzheimer's and stroke.

Spectrum Pharmaceuticals Acquires Worldwide License to EndothelinB Agonists for Enhancing Delivery of Chemotherapeutics to Tumors

     -  The novel approach developed at University of Illinois and

        Chicago Labs takes advantage of unique properties of tumor blood

        supply.

     -  In animal models of human cancer, administration of endothelinB

        agonists prior to paclitaxel increased the levels of paclitaxel in

        the tumor by more than 400%, while not significantly affecting

        paclitaxel concentration in normal tissues.

     -  Novel approach has the potential to enhance the therapeutic index

        (increase the efficacy and reduce the toxicity) of marketed

        chemotherapeutic agents by selectively improving tumor blood

        perfusion and increasing delivery of anti-cancer agents to tumor

        tissue.

IRVINE